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Mutation in BRCA2 compromises the interaction with replication protein A.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- "Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA double strand break repair. Both BRCA1 and BRCA2 have also been implicated in transcription by RNA polymerase II, for both proteins have domains which, when tethered adjacent to a promoter, can activate transcription," researchers in Canada report.
"We have used protein affinity chromatography and coimmunoprecipitation techniques to show that the putative N-terminal acidic transcriptional activation domain of BRCA2 interacts with replication protein A (RPA), a protein essential for DNA repair, replication, and recombination. This interaction was not mediated by DNA and was specific for human RPA but not yeast RPA. Since the cancer predisposing mutation Y42C in BRCA2 significantly compromised the interaction between RPA and BRCA2, this interaction may be biologically important. That BRCA2 protein in HeLa cell extract also coimmunoprecipitated with RPA suggested that this ...
- Mutation in BRCA2 compromises the interaction with replication protein...
- Newspaper article from: Cancer Weekly March 4, 2003 700+ words
...early onset breast cancer. Both the BRCA1...interacts with replication protein A (RPA), a...between BRCA2 and replication protein A is compromised...Oncology, Breast Cancer, Replication Protein A, Proteomics...
- Mutation in BRCA2 compromises the interaction with replication protein A.
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Source: HighBeam Research, Mutation in BRCA2 compromises the interaction with replication...