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Immunohistochemical distinction of invasive from noninvasive breast lesions.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Identification of myoepithelial cells using antibodies to cytoskeletal proteins, such as smooth muscle myosin heavy chain (SMM-HC) and calponin, can play an important role in distinguishing invasive carcinoma from its histologic mimics. However, antibodies to these proteins may also cross-react with stromal myofibroblasts and vascular smooth muscle cells. It has recently been demonstrated that myoepithelial cells express the nuclear protein, p63, a member of the p53 gene family.
"We compared the patterns of reactivity of antibodies with p63, calponin, and SMM-HC on 85 breast lesions, including 11 cases of sclerosing adenosis, 33 cases of ductal carcinoma in situ, including 10 that showed microinvasion, 6 cases of lobular carcinoma in situ, and 35 cases of infiltrating ductal carcinoma. All three antibodies were positive on the vast majority of myoepithelial cells in all cases.
"A small minority of cases showed focal gaps in the revealed myoepithelial cell layer, reflected in discontinuous positive immunostaining around noninvasive epithelial nests (including ductal carcinoma in situ). No case showed p63 expression by myofibroblasts or vascular smooth muscle cells, whereas myofibroblasts expressed, in 8% and 76% of cases, SMM-HC and calponin, respectively.
"Although no tumor cell reactivity was noted with antibodies to calponin or SMM-HC, tumor cells in 11% of cases showed at least focal p63 expression," wrote R.W. Werling and ...
- Breast Lesions Evaluation.
- Newspaper article from: Radiology Alert September 1, 2000 700+ words
Breast Lesions Evaluation Abstract & Commentary...lesions. Source: Kvistad KA, et al. Breast Lesions: Evaluation with dynamic contrast...contrast-enhanced properties of breast lesions. Results have invariably reported...
- Doppler imaging may have value for differentiating focal breast lesions.
- Newspaper article from: Angiogenesis Weekly April 4, 2003 700+ words
...have value for differentiating focal breast lesions. "The purpose of this article is...ultrasound (US) in differentiating focal breast lesions with special regard on power Doppler...agents. The sonographic evaluation of breast lesions has become a standard procedure during...
- Cystic hypersecretory breast lesions encompass a spectrum of pathologic lesions.
- Newspaper article from: Clinical Oncology Week April 19, 2004 700+ words
...NewsRx.net) -- Cystic hypersecretory breast lesions may encompass a spectrum of pathologic...lesions of the breast are rare. These breast lesions include cystic hypersecretory hyperplasia...suggests that cystic hypersecretory breast lesions encompass a spectrum of pathologic...
- Fine-needle aspiration is less sensitive than core biopsy of breast lesions.
- Newspaper article from: Biotech Week January 28, 2004 700+ words
...highly accurate method for diagnosing breast lesions. However, in recent years there has...and CB in palpable and nonpalpable breast lesions," wrote A. Berner and colleagues...vs. core biopsy in the diagnosis of breast lesions. Diagn Cytopathol, 2003;29(6...
- Subtraction algorithms better visualize suspicious breast lesions.(Brief...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...Korea stated. "Twenty-five patients with suspicious breast lesions underwent dynamic CE MRM using 3D fast low-angle shot...subtraction algorithm is adequate for screening malignant breast lesions and can potentially replace the time-intensity profile...
- New instrumentation allows for removal of nonpalpable breast lesions.
- Magazine article from: AORN Journal Boshaw, Doris L. August 1, 1997 700+ words
...have had a major impact on the diagnosis of nonpalpable breast lesions. Stereotactic and ultrasound-guided imaging provide accuracy...established as the preferred method for removing indeterminate breast lesions. A new breast biopsy instrumentation system combines digital...
- Kinetic variable most useful for identifying malignant MRI-detected breast...
- Newspaper article from: NewsRx Health September 6, 2009 700+ words
...significantly in distinguishing benign from malignant suspicious breast lesions on MRI, according to a study published in the September...computer-aided evaluation variables of 125 suspicious breast lesions. Three different kinetic curves (washout, plateau and...
- Endothelin and its receptors signal the malignant potential of breast lesions.
- Newspaper article from: Angiogenesis Weekly May 14, 2004 700+ words
...Endothelin and its receptors signal the malignant potential of breast lesions. "Endothelin-1 (ET-1) is overexpressed in breast...aggressive behavior and invasive potential of premalignant breast lesions," study coauthors wrote. Wulfing and colleagues published...