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Combining risperidone, fluvoxamine may enhance response rate. (Initial Depression Treatment).

The Brown University Geriatric Psychopharmacology Update

| February 01, 2003 | Lam, Y.W. Francis | This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Selective serotonin reuptake inhibitors (SSRIs) have been shown to be effective and safe in management of depression but not all patients respond to therapy. For management of these non-responders, adding atypical antipsychotics has been proposed as a potential treatment strategy. Augmentation therapy with either risperidone (Risperdal) or olanzapine (Zyprexa) in patients not responding to SSRIs has been reported to produce rapid and adequate therapeutic response. (1,2)

To further evaluate the potential beneficial effect of adding an atypical antipsychotic drug at the initiation of SSRI therapy, researchers recently conducted a first of its kind clinical study in 36 depressed patients ranging in age from 18 to 81 years old. Since the use of antipsychotics and antidepressants can…

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