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Growth factor activates enzyme that associates with cancer metastasis.
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- High levels of vascular endothelial growth factor in the abdominal fluid of ovarian cancer patients may be responsible for cancer metastasis.
According to a study from Japan, "the role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic fluid were examined in patients with ovarian cancer and benign ovarian tumor. The effect of ascites on cell growth, cell invasion activity and angiogenesis was investigated in vitro."
"Ascitic fluid and tumor tissue samples were obtained from 15 patients with benign ovarian tumor and 24 patients with ovarian carcinoma. Tissue extract and ascitic fluid levels of VEGF were measured using enzyme immunoassay. Tumor microvessels were detected immunohistochemically. MMP activity was measured by gelatin zymography," said H. Yabushita and coauthors, Aichi Medical University, School of Medicine.
"For the in vitro experiment, the SKOV-3 human ovarian carcinoma cell line was utilized. Cell growth was examined using MTT-assay, cell invasion activity was measured by Matrigel in vitro invasion assay, and neovascularization was assessed using an angiogenesis kit."
"VEGF levels in tissue extract and ascitic fluid, MVD, expression of active form MMP-2 in ascitic fluid and ascites volume were higher in ovarian cancer patients than in benign ovarian tumor patients. In addition, these were elevated in stage III and IV diseases compared to stage I and 11 diseases in ovarian cancer patients," the researchers announced.
"MVD and expression of active form MMP-2 in ascitic ...
- Complement and immunoglobulin levels in serum and ascitic fluid of patients...
- Magazine article from: Southern Medical Journal Yildirim, Bulent Sari, Ramazan Sezgin, Nurzen Sevinc, Alper Hilmioglu, Fatih October 1, 2002 700+ words
...complement and immunoglobulin levels in ascitic fluid and serum of 47 patients with spontaneous...also done. Results. The highest serum and ascitic fluid C3 and C4 levels and ascitic fluid IgM, IgA, and IgG levels were found in...
- Disseminated peritoneal tuberculosis mimicking metastatic ovarian cancer. (Case...
- Magazine article from: Southern Medical Journal Zaidi, S. Nasir H. Conner, Michael December 1, 2001 700+ words
...tissue sections and ascitic fluid were negative for fungi...Mycobacterium tuberculosis. Ascitic fluid cultures became positive...sister had died of ovarian cancer. Physical examination...addition, 8 L of yellow ascitic fluid were removed. Postoperative...
- New ovarian cancer study findings have been reported by S.B. Ingersoll and...
- Newspaper article from: Blood Weekly March 5, 2009 700+ words
...Current therapies for ovarian cancer (OC) patients have...solid tumor and ascitic fluid were collected, analyzed...colleagues (see also Ovarian Cancer). The researchers...with PBMC against ovarian cancer: Development of an...
- Molecular abnormalities exist in the peritoneal fluid of ovarian cancer...
- Newspaper article from: Cancer Vaccine Week September 15, 2003 700+ words
...peritoneal fluid of ovarian cancer patients. "To determine...peritoneal wash or ascitic fluid) in three of the...from patients with ovarian cancer and may be used to...detection of primary ovarian cancer." Parrella and colleagues...
- Treatment of Ovarian Cancer with Autologous, Hapten-Modified Tumor Cell Vaccine.
- Newspaper article from: Immunotherapy Weekly June 28, 1999 700+ words
...Ovarian) "Treatment of Ovarian Cancer with Autologous, Hapten...approach is applicable to ovarian cancer. In group #1 (minimal...by surgery or from ascitic fluid. Starting 1-3 months...feasible in patients with ovarian cancer and induces cell...
- Ovarian cancer strikes one in 68 women: Now experts agree on a set of symptoms...
- Newspaper article from: Tulsa World (Tulsa, OK) August 2, 2007 700+ words
...estimated 15,000 Americans die of ovarian cancer, where malignant cells are found in...organs, the ovaries. For a long time, ovarian cancer was called the "silent killer" because...poor. Almost 70 percent of women with ovarian cancer are not diagnosed until the disease...
- Ovarian Cancer; Facts to Know.
- Newspaper article from: NWHRC Health Center - Ovarian Cancer March 16, 2005 700+ words
* What is ovarian cancer? There are almost 40 different types of ovarian cancer. However, nine out of 10 ovarian cancer patients have a common epithelial tumor, which begins in the surface tissue of the ovary (epithelium). * What causes ovarian...
- Ovarian Cancer
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Rastegari, Esther; Frey, Rebecca January 1, 2006 700+ words
Ovarian Cancer Definition Ovarian cancer is cancer of the ovaries, the egg-releasing and hormone...located. Although it is a distinct disease, it is linked with ovarian cancer. This is because the ovarian and peritoneal cells have the...
