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Spinal cord's neurons with estrogen receptor-alpha upregulated during pregnancy.
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- "Estrogen receptor (ER) immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of estrogen receptor alpha-in the spinal cord during different stages of pregnancy and to determine whether ERalpha-expressing neurons are related to uterine afferent nerves bringing information to the spinal cord at parturition," researchers in the United States report.
"Immunohistochemistry showed ER-alpha immunoreactive neurons in the dorsal half of the spinal cord, i.e., dorsal horn, dorsal intermediate gray areas (dorsal commissural nucleus), and around the central canal and sacral parasympathetic autonomic nucleus of the lumbosacral spinal cord. Neurons in these areas corresponded topographically to the distribution of central processes of visceral primary afferent neurons (e.g., containing calcitonin gene related peptide and substance P) that innervate and activate second order spinal cord neurons (evidenced by their expression of Fos) at parturition. Western blots showed that ERalpha increases in the spinal cord, with a peak at day 20 of gestation, followed by a slight decrease by 2 days postpartum. These studies ...
- Spinal cord's neurons with estrogen receptor-alpha upregulated during pregnancy.
- Newspaper article from: OBGYN & Reproduction Week February 10, 2003 700+ words
...net) -- "Estrogen receptor (ER) immunoreactivity...present in spinal cord neurons in...expression of estrogen receptor alpha-in the spinal cord during different...Research (Estrogen receptor-alpha and...circuits to the spinal cord during ...
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Source: HighBeam Research, Spinal cord's neurons with estrogen receptor-alpha upregulated during...