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E. coli-expressed zona pellucida glycoproteins have contraceptive properties.
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- "In order to evaluate the immunocontraceptive potential of zona pellucida (ZP) glycoproteins, recombinant bonnet monkey (Macaca radiata) zona pellucida glycoprotein-1 (r-bmZP1) and -2 (r-bmZP2) were expressed as polyhistidine fusion proteins in Escherichia coli. Female bonnet monkeys were immunized with the purified r-bmZP1 (n = 5) and r-bmZP2 (n = 4) conjugated to diphtheria toxoid (DT). Immunization led to generation of antibodies against r-bmZP1, r-bmZP2 and DT as determined by enzyme linked immunosorbent assay," researchers in India report.
"The immunized animals exhibited normal menstrual cyclicity and progesterone profile, except during the summer amenorrhoea," said Chhabi K. Govind and collaborators at the National Institute of Immunology in New Delhi. "Immunized animals, when mated with males of proven fertility, showed protection from conceiving for cumulative 45 ovulatory cycles in r-bmZP1-DT immunized group and 32 ovulatory cycles in r-bmZP2-DT immunized group. Ovarian histopathology of both the immunized groups revealed the presence of atretic follicles with degenerated oocytes, which may have been the principle cause for the failure of immunized animals to conceive in spite of the decline in either ...
- E. coli-expressed zona pellucida glycoproteins have contraceptive properties.
- Newspaper article from: Vaccine Weekly February 12, 2003 700+ words
...potential of zona pellucida (ZP) glycoproteins...radiata) zona pellucida glycoprotein...collaborators at the National Institute of Immunology...human primate zona pellucida glycoproteins...Laboratory, National Institute of Immunology...
- Zonagen Suspends Further Research On Zona Pellucida Contraceptive Vaccine.
- Press release article from: Business Wire September 27, 2001 700+ words
...has suspended further research on a zona pellucida based contraceptive vaccine following...immunization with a primate recombinant zona pellucida protein. Though contraception was...published studies, a human recombinant zona pellucida immunocontraceptive vaccine consistently...
- Vam6P and SNAP involved in sperm-zona pellucida interactions.
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...Vam6P and SNAP are involved in sperm-zona pellucida interactions. According to a study...Antibodies to VAMP and SNAP inhibited sperm zona pellucida interaction, suggesting their possible...spermatozoa and their involvement in sperm-zona pellucida interactions. Biochem Biophys Res...
- zona pellucida
- Reference information from: The Mosby Medical Encyclopedia October 1, 1996 700+ words
The Mosby Medical Encyclopedia 10-01-1996 zona pellucida /pul'sidu/, the thick, transparent, noncellular membrane that encloses the egg (ovum). It is released by the ovum during...
- Effect of in vitro culture of mammalian embryos on the architecture of the zona...
- Magazine article from: The Biological Bulletin Silva, Celso P. Silva, Vanessa Kommineni, Karpura Keefe, David October 1, 1997 700+ words
The mammalian zona pellucida (zona) is composed of glycoprotein filaments organized in three layers that differ in their orientation and birefringence (1...
- Publication No. WO/2009/126648 Published on Oct. 15, Assigned to Auburn...
- News wire article from: US Fed News Service, Including US State News October 20, 2009 700+ words
...Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff and Kent Van kampen, all from the U.S., have developed a zona pellucida binding peptides, expression vectors, compositions, and methods for species-specific immunocontraception of animals...
- FEARS LIMIT BIRTH CONTROL OPTIONS IN US
- Newspaper article from: The Boston Globe Judy Foreman, Globe Staff April 23, 1989 700+ words
...Council in New York and the National Institute of Immunology in Delhi...protective layer called the zona pellucida. In the last few years...have discovered that the zona pellucida contains special molecules...that would surround the zona pellucida, making it ...
- Findings from P. Bansal and co-authors provide new insights into baculovirus.
- Newspaper article from: Immunotherapy Weekly October 28, 2009 700+ words
...spermatozoa to bind to the zona pellucida (ZP), an extracellular...spermatozoa to human zona pellucida glycoprotein-3...recombinant human zona pellucida glycoprotein-3...contact S.K. Gupta, National Institute Immunology, Reproductive...
Source: HighBeam Research, E. coli-expressed zona pellucida glycoproteins have contraceptive...