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Antisense oligodeoxynucleotide to p21(Waf1/Cip1) suppresses tumor growth.(Brief Article)
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- Antisense molecules can prevent angiogenesis and tumor growth in mice implanted with human breast cancers.
"Under some conditions, p21(Waf1/Cip1) plays an assembly factor role for the cyclins and cyclin-dependent kinases, and recent reports demonstrate that p21 can act as an anti-apoptotic protein. Thus, it is logical to exploit this function of p21 as an anticancer target. We have performed a pilot study showing that daily subcutaneous injection of a phosphorothioate antisense p21 oligodeoxynucleotide, which we have previously shown to attenuate p21 levels in vitro, into nude mice who have been implanted with highly metastatic breast cancer cells results in inhibition of tumor growth and angiogenesis," researchers in the United States said.
"Inhibition of in vitro endothelial capillary formation confirms that these oligodeoxynucleotides have a direct effect upon tumor angiogenesis," commented R.H. Weiss and colleagues, University of California Davis, Department of Internal Medicine.
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