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Exercise and genistein combination prevent bone loss in male mice.
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- New research suggests hormones are just important for maintaining bone health in men as they are in women. Exercise and plant estrogens may help men to overcome hormone deficiency, researchers say.
"There is evidence that estrogen plays an important role in skeletal tissue in males as well as females. We have reported that phytoestrogens, such as genistein, selectively act on bone and exhibit cooperative effects on bone mass when combined with exercise in ovariectomized mice. In this study, we examined whether both interventions exhibit cooperative effects on bone loss in androgen-deficient mice similar to those in estrogen-deficient mice," researchers in Japan stated.
"Male mice aged 7 weeks were either sham operated or orchidectomized (ORX) and divided into six groups: 1) sham; 2) ORX; 3) ORX and treated with genistein (0.4 mg/day) subcutaneously; 4) ORX, exercised on a treadmill daily for 30 min/day at 12 m/min; 5) ORX, given genistein, and exercised (ORX+ExG); and 6) ORX and treated with 17 beta-estradiol (E-2)," described J. Wu and colleagues, National Institute for Health and Nutrition, Division of Food Science.
"Four weeks after the intervention, seminal vesicle weight strikingly decreased in ORX mice, and it was not affected by administration of genistein or E-2. Bone mineral density of whole femur was significantly reduced by ORX, and bone loss was prevented by the combined ...
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