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Inhaled corticosteroids may increase risk for fracture after hip injury.
2003 FEB 13 - (NewsRx.com & NewsRx.net) -- Inhaled corticosteroids may increase the risk for hip fracture because of its effects on bone mineral density.
According to a study from England, "there is accumulating evidence that the use of inhaled corticosteroids is associated with a dose-related reduction in bone mineral density. Whether this translates to an increase in fracture is unclear. We have used the General Practice Research Database to perform a case-control analysis, including 16,341 cases of hip fracture (mean age of 79 years, 79% female, median period prescribing data 2.7 years) and 29,889 control subjects, individually matched by age, sex, and general practice."
"Data for all prescriptions for corticosteroids and for potential confounders, including other drug use and comorbid illnesses, were extracted, and the impact of inhaled corticosteroid exposure was analyzed using conditional logistic regression," stated R.B. Hubbard and coauthors, University of Nottingham, City Hospital.
"The risk of hip fracture was associated with exposure to inhaled corticosteroids with an odds ratio of 1.26 (95% confidence interval, 1.17 to 1.36). This odds ratio was reduced after adjusting the model for annual courses of oral corticosteroids, the ...
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Source: HighBeam Research, Inhaled corticosteroids may increase risk for fracture after hip...