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Weak B cell receptor engagement can stimulate IgM immune response.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "The quasi-monoclonal mouse has limited B cell diversity, whose major (approximately 80%) B cell antigen receptors are comprised of the knockin V[subscript]H 17.2.25 (V[subscript]HT)-encoded H chain and the lambda-1 or lambda-2 L chain, thereby being specific for 4-hydroxy-3-nitrophenylacetyl. The p-nitrophenylacetyl (pNP) was found to be a low affinity analog of nitrophenylacetyl. We examined affinity maturation of anti-pNP IgG by analyzing mAbs obtained from quasi-monoclonal mice that were immunized with this low affinity antigen."
Naoki Kanayama and colleagues at Okayama University reported four major results from their study. "1) Although V[subscript]HT/lambda-1 and V[subscript]HT/lambda-2 IgM were equally produced, V[subscript]HT/lambda-2 IgG almost exclusively underwent affinity maturation toward pNP. 2) A common mutation in complementarity-determining region 3 of V[subscript]HT (T313A) mainly contributed to generating the specificity for pNP. 3) Because mutated V[subscript]HT-encoded gamma-chains could form lambda-1-bearing IgG in Chinese hamster ovary cells, apparent absence of V[subscript]HT/lambda-1 anti-pNP IgG may not be due to the incompatibility between the gamma-chains and the lambda-1-chain, but may be explained by the fact that V[subscript]HT/lambda-1 B ...
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Source: HighBeam Research, Weak B cell receptor engagement can stimulate IgM immune response.