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Nippostrongylus brasiliensis induces antigen-specific immune response.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Th2 immune responses to a number of infectious pathogens are dependent on B7-1/B7-2 costimulatory molecule interactions. We have now examined the Th2 immune response to Nippostrongylus brasiliensis (Nb) in B7-1/B7-2(-/-) mice and show that Th2 effector cells develop that can mediate worm expulsion and produce substantial Th2 cytokines comparable with wild-type infected mice; however, in marked contrast, B cell antigen-specific antibody production is abrogated after 137 blockade."
"To examine the mechanism of T cell activation, OVA-specific DO11.10 T cells were transferred to recipient mice, which were then immunized with a combination of Nb plus OVA or either alone," reported Zhugong Liu and collaborators at the Uniformed Services University of the Health Sciences in Bethesda, Maryland, Harvard Medical School in Boston, Massachusetts, and the U.S. Department of Agriculture in Beltsville, Maryland. "Only the combination of Nb plus OVA triggered T cell differentiation to OVA-specific Th2 cells, suggesting that Nb acts as an adjuvant to stimulate antigen-specific naive T cells to differentiate to ...
- Nippostrongylus brasiliensis induces antigen-specific immune response.
- Newspaper article from: Immunotherapy Weekly February 12, 2003 700+ words
...response to Nippostrongylus brasiliensis (Nb) in B7...the Uniformed Services University of the Health...Immunology (Nippostrongylus brasiliensis can induce...Uniformed Services University of the Health...
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