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Adenoviral vector encoding for hepatitis C virus molecule prevents infection.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- A recombinant vaccine comprised of the hepatitis C virus (HCV) NS3 protein and an adenoviral vector has induced immune response in animal models.
According to a study from Spain, "cellular immune response plays an important role in the clearance of hepatitis C virus (HCV). Thus, development of efficient ways to induce anti-viral cellular immune responses is an important step toward prevention and/or treatment of HCV infection. With this aim, we have constructed a replication-deficient recombinant adenovirus expressing HCV NS3 protein (RAdNS3)."
"The efficacy of RAdNS3 was tested in vivo by measuring the protection against infection with a recombinant vaccinia virus expressing HCV-polyprotein (vHCV1-3011). Immunization with 10(9) pfu of RAdNS3 induced anti-NS3 humoral, T helper and T cytotoxic responses," stated L. Arribillaga and coauthors, University of Navarra, CIMA.
"We identified eight epitopes recognized by IFN-gamma producing cells, five of them exhibiting lytic activity. Moreover, we show that RAdNS3 immunized mice were protected against challenge with vHCV1-3011 and that this protection was mediated by ...
- Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer...
- Newspaper article from: NewsRx Health July 12, 2009 700+ words
...Gastroenterology. They present a novel adenoviral vector that binds to the EphA2 receptor...capsid. The ablated retargeted adenoviral vector was produced on 293T cells...Specific targeting of this novel adenoviral vector to pancreatic cancer was investigated...
- Adenoviral vector containing tumor-specific constructs target ovarian cancer.
- Newspaper article from: Gene Therapy Weekly September 2, 2004 700+ words
...com & NewsRx.net) -- Adenoviral vector containing tumor-specific constructs...we have reported on a recombinant adenoviral vector system (AdLP-) in which the expression...study was to generate a recombinant adenoviral vector system which would generate tumor...
- Mini-adenoviral vector extends clotting factor production in hemophilia models.
- Newspaper article from: Blood Weekly January 29, 2004 700+ words
...amp; NewsRx.net) -- Mini-adenoviral vector extends clotting factor production...was constructed based on the mini-adenoviral vector GT2073 (mini-Ad vector) with...At the same time, previous normal adenoviral vector pAdSPi'IX containing viral genome...
- Introgen's Adenoviral Vector Demonstrates Safety in Phase II Study; Biosafety...
- Press release article from: PR Newswire June 2, 2001 700+ words
...safety of its extensively tested adenoviral vector for gene therapy. Results from a...Biological Safety of INGN 201, an Adenoviral Vector For Gene Therapy: Data From 190...INGN 201 is a replication-impaired adenoviral vector carrying the human p53 tumor suppressor...
- A non-replicating adenoviral vector as a potential HIV vaccine.(Presentations)
- Magazine article from: Research Initiative/Treatment Action! Shiver, John March 22, 2003 700+ words
...including a non-replicating adenoviral vector, have been studied in animals and...presentation, "A non-replicating adenoviral vector as a potential HIV vaccine," began...that was not seen in animals given adenoviral vector vaccines. Viral control was best...
- A Semipermissive Host Model Tolerated an Adenoviral Vector.
- Newspaper article from: Gene Therapy Weekly February 8, 1999 700+ words
An E1A-deficient adenoviral vector was well tolerated in a semipermissive...Replication of an E1A-Deficient Adenoviral Vector after Intracardiac Delivery...delivery of an E1-deleted adenoviral vector at 3x10(9) to 3x10(11...
- Expression of Tissue Inhibitor of Matrix Metalloproteinases 1 by Use of an...
- Newspaper article from: Gene Therapy Weekly August 16, 1999 700+ words
...Metalloproteinases 1 by Use of an Adenoviral Vector Inhibits Smooth Muscle Cell Migration...cells (SMCs) with Av1.TIMP1 (an adenoviral vector containing the human TLMP1 cDNA...power field, P<0.05). The adenoviral vector was delivered to the injured rat...
- Adenoviral vector HIV vaccine stimulates enhanced mucosal IgA response.
- Newspaper article from: Vaccine Weekly October 29, 2003 700+ words
...NewsRx.com & NewsRx.net) -- An intranasal adenoviral vector human immunodeficiency virus vaccine stimulated an enhanced...Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in...
