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Protection against H. pylori is IL-12-dependent and mediated by Th1 cells.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "The regulatory roles of Th1 and Th2 cells in immune protection against Helicobacter infection are not clearly understood. In this study, we report that a primary H. pylori infection can be established in the absence of IL-12 or IFN-gamma," researchers in Sweden and the United States report.
"However, IFN-gamma, but not IL-12, was involved in the development of gastritis because IFN-gamma(-/-) (GKO) mice exhibited significantly less inflammation as compared with IL-12(-/-) or wild-type (WT) mice," said Ali A. Akhiani and colleagues at the University of Goteborg in Sweden and AstraZeneca R&D Boston in the United States. "Both IL-12(-/-) and GKO mice failed to develop protection following oral immunization with H. pylori lysate and cholera toxin adjuvant. By contrast, Th2-deficient, IL-4(-/-), and WT mice were equally well protected."
The investigators found that "mucosal immunization in the presence of co-administered rIL-12 in WT mice increased antigen-specific IFN-gamma-producing T cells by 5-fold and gave an additional 4-fold reduction in colonizing bacteria, confirming a key role of Th1 cells in protection. Importantly, only protected IL-4(-/-) and WT mice demonstrated substantial influx of CD4+ T cells in the gastric mucosa. The extent of inflammation in challenged IL-12(-/-) and GKO mice was much reduced compared with that in WT mice, indicating that IFN-gamma/Th1 cells also play a major role in postimmunization gastritis. Of note, ...
- Protection against H. pylori is IL-12-dependent and mediated by Th1 cells.
- Newspaper article from: Biotech Week February 12, 2003 700+ words
...inflammation as compared with IL-12(-/-) or wild-type (WT) mice," said Ali A. Akhiani...contrast, Th2-deficient, IL-4(-/-), and WT mice were equally well protected...Importantly, only protected IL-4(-/-) and WT mice demonstrated substantial...
- IL-10 modulates Pneumocystis carinii-induced lung damage.
- Newspaper article from: AIDS Weekly March 3, 2003 700+ words
...addition, "CD4-depleted IL-10 KO mice had significantly...injury than CD4-depleted WT mice even though the intensity...researchers concluded that "IL-10 down-regulates...response to P. carinii in WT mice; however, in the absence of CD4+ T cells, IL-10 plays a critical...
- Loss induced by IL-1 requires expression of either NF-kB p50 or p52.
- Newspaper article from: Cancer Weekly March 25, 2003 700+ words
...during embryonic development) in IL-1 induced resorption, we used...double KO (dKO) mice. "IL-1 increased blood calcium and bone...4KO compared with single KO and wt mice treated with IL-1. IL-1 receptor expression...
- Research on angiogenesis discussed by scientists at Kanazawa University.
- Newspaper article from: Angiogenesis Weekly November 20, 2009 700+ words
...ra) knockout (KO) mice and anti-IL-1ra antibody-treated WT mice 2 weeks after injury." "Angiogenic...macrophages, but not neutrophils, expressed IL-1ra. Compared with WT mice, either IL-1ra KO mice or anti-IL-1ra antibody...
- Scientists at Ben-Gurion University release new data on fibrosarcoma.
- Newspaper article from: Biotech Week June 17, 2009 700+ words
...progressive tumors in WT mice, while surprisingly, lines from IL-1 alpha...fibrosarcoma cell lines from IL-1 alpha...compared with lines from WT mice, manifested higher...cells were observed in IL-alpha 1(-/-) mice, in contrast to WT mice. Thus, we demonstrate...
- Data on apoptosis detailed by M. Aoyama and co-authors.(Report)
- Newspaper article from: Blood Weekly November 5, 2009 700+ words
...independent of endogenous IL-18. Nevertheless, levels of IL-18 in the blood of WT mice were significantly higher...in KO mice compared with WT mice only in males. This indicates that endogenous IL-18 production decreases...
- Research results from University of Sao Paulo update understanding of life...
- Newspaper article from: Life Science Weekly September 16, 2008 700+ words
...lungs was greater in WT mice. In histopathological...seen in both WT and IL-18(-/-) mice...clearance observed in WT mice. TNF-alpha augmented...in the infection of WT mice, seemingly to compensate high levels of IL-10," wrote L...
- Investigators at University of Glasgow have published new data on...
- Newspaper article from: Biotech Week March 11, 2009 700+ words
...mice produced less IL-17 and IFN-gamma than did those of the WT mice. In contrast, Gal...mice produced more serum IL-10, IL-5, and IL...in the CNS than did the WT mice. Furthermore, bone marrow...mice produced more IL-10 in response to LPS...
Source: HighBeam Research, Protection against H. pylori is IL-12-dependent and mediated by Th1...