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Virion-based vaccine protects animals against disease.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A DNA vaccine containing viral particles prevents many symptoms of infection in primates exposed to the simian version of HIV (SIV), researchers in Maryland report.
To be effective, an HIV vaccine "will very likely have to elicit both cellular and humoral immune responses to control HIV-1 strains of diverse geographic and genetic origins," according to Ronald L. Willey and colleagues working at the National Institutes of Health in Bethesda, the National Cancer Institute in Frederick and Rockville-based Bioqual, Inc.
A virion-based vaccine induced both cell- and antibody-mediated responses to SIV, and protected animals from disease despite imperfect virologic control, Willey and coauthors said.
The researchers evaluated the efficacy of a vaccine containing inactivated but intact HIV and SIV virions, in addition to vaccinia virus engineered to express key viral proteins. Inoculated rhesus macaques demonstrated virus-specific cytotoxic T-cell activity and neutralizing antibody responses after exposure to simian-human immunodeficiency virus (SHIV), a highly virulent viral chimera containing genes from both HIV and SIV, according to the report.
Vaccinated animals remained healthy for at least 15 months after SHIV challenge, and maintained nearly normal CD4 cell counts during this time, study data showed. However, immunization did not protect macaques against ...
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Source: HighBeam Research, Virion-based vaccine protects animals against disease.