AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Combined intrarectal/intradermal inoculation boosts M. bovis-based vaccine efficacy.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- Researchers in Japan have identified a method for improving the protection afforded by Mycobacterium bovis bacillus Calmette-Guerin (rBCG)-based HIV vaccines.
An effective rBCG-based vaccine will have to elicit "high levels of HIV-1-specific immunity while at the same time maintaining immunity to tuberculosis," explained M. Kawahara and colleagues, National Institute of Infectious Diseases.
The researchers investigated "a combined vaccination strategy for enhancement of immune responses specific for HIV-1," according to their report. "Guinea pigs were inoculated with either a single or combination intradermal (i.d), intrarectal (i.r.) and intranasal (i.n.) administration of rBCG-pSOV3J1 which secretes a chimeric protein of HIV-1 V3J1 peptide and alpha-antigen."
"Significant levels of delayed-type hypersensitivity to both V3J1 peptide and tuberculin was induced in guinea pigs inoculated with human doses of rBCG-pSOV3J1 by a combination of intrarectal and intradermal routes," study data showed. "Guinea pigs inoculated by combined routes also had significantly higher titers of HIV-1-specific serum IgG and IgA compared with those animals immunized only intrarectally, which led to the enhanced neutralization activity against HIV-1(MN)."
...- NIAID HIV/AIDS pathogenesis research agenda. (National Institute of Allergy and...
- Newspaper article from: AIDS Weekly Johnston, M.I. Killen, J.M. March 7, 1994 700+ words
...mechanisms that underlie HIV pathogenesis is critical...therapeutic strategies. The National Institute of Allergy and Infectious...development of an effective HIV vaccine. The National Institute of Allergy and Infectious...Disease has developed an HIV/AIDS Research Agenda...
- Immune reconstitution of HIV-infected individuals. (National Institute of...
- Newspaper article from: AIDS Weekly August 16, 1993 700+ words
...AI-93-012, National Institute of Allergy and Infectious...The [U.S.] National Institute of Allergy and Infectious...and the [U.S.] National Institute of Diabetes and Digestive...Immunodeficiency Virus-1 (HIV-1) with the immune...
- Neuro-AIDS: HIV-1 infection and the nervous system. (National Institute of...
- Newspaper article from: AIDS Weekly August 17, 1992 700+ words
...Disorders and Stroke, National Institute of Mental Health. "Purpose: The National Institute of Neurological Disorders...Stroke (NINDS) and the National Institute of Mental Health (NIMH...immunodeficiency virus (HIV) infection (neuro...
- Detection of HIV-infected cells in saliva. (National Institute of Dental...
- Newspaper article from: AIDS Weekly July 8, 1991 700+ words
National Institute of Dental Research Cells infected with HIV are present in the saliva...study by researchers in the National Institute of Dental Research (NIDR...Laboratory of Oral Medicine. HIV is readily detected in most...
- Hearing impairment and other communication disorders associated with CMV...
- Newspaper article from: AIDS Weekly October 5, 1992 700+ words
...Number: PA-92-107. National Institute on Deafness and Other...and Disorders of the National Institute on Deafness and Other...immunodeficiency virus (HIV) infection or with...clarify the role of CMV, HIV, AIDS and therapeutic...
- HIV therapy recommendations issued. (U.S. National Institute of Allergy and...
- Newspaper article from: AIDS Weekly December 20, 1993 700+ words
HIV-infected patients and their...experts convened by the U.S. National Institute of Allergy and Infectious...intermediate and late stages of HIV disease." The recommendations...scenarios for patients with HIV followed by antiretroviral...
- NIAID expands HIV vaccine clinical trial sites. (National Institute of Allergy...
- Newspaper article from: AIDS Weekly July 25, 1994 700+ words
HIV Vaccines The following is...the U.S. NIAID: "The National Institute of Allergy and Infectious...NIAID) recently increased its HIV vaccine clinical trial sites...first Phase II trial of two HIV vaccines, the first trial...
- HIV vaccines move into Phase II testing in uninfected volunteers. (U.S....
- Newspaper article from: AIDS Weekly December 28, 1992 700+ words
...experimental vaccines to prevent HIV disease has begun in Seattle...Units sponsored by the U.S. National Institute of Allergy and Infectious Diseases...products based on gp120, one of HIV's envelope proteins. The...are pleased that progress in HIV vaccine research allows us...
- Women's interagency HIV study begins. (U.S. National Institute of Allergy and...
- Newspaper article from: AIDS Weekly July 12, 1993 700+ words
...announced that the U.S. National Institute of Allergy and Infectious...investigate the impact of HIV on U.S. women. The...the Women's Interagency HIV Study (WIHS), will study the signs and symptoms of HIV infection in women, describe...
- Determinants of effective HIV counseling. (National Institute on Drug Abuse...
- Newspaper article from: AIDS Weekly May 10, 1993 700+ words
...might be usefully applied to HIV prevention efforts, such as...systematically examined in HIV counseling are characteristics...possibility of negative effects of HIV counseling has been examined...Division of Clinical Research, National Institute on Drug Abuse, 5600 Fishers...
Source: HighBeam Research, Combined intrarectal/intradermal inoculation boosts M. bovis-based...