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E. coli-expressed zona pellucida glycoproteins have contraceptive properties.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "In order to evaluate the immunocontraceptive potential of zona pellucida (ZP) glycoproteins, recombinant bonnet monkey (Macaca radiata) zona pellucida glycoprotein-1 (r-bmZP1) and -2 (r-bmZP2) were expressed as polyhistidine fusion proteins in Escherichia coli. Female bonnet monkeys were immunized with the purified r-bmZP1 (n = 5) and r-bmZP2 (n = 4) conjugated to diphtheria toxoid (DT). Immunization led to generation of antibodies against r-bmZP1, r-bmZP2 and DT as determined by enzyme linked immunosorbent assay," researchers in India report.
"The immunized animals exhibited normal menstrual cyclicity and progesterone profile, except during the summer amenorrhoea," said Chhabi K. Govind and collaborators at the National Institute of Immunology in New Delhi. "Immunized animals, when mated with males of proven fertility, showed protection from conceiving for cumulative 45 ovulatory cycles in r-bmZP1-DT immunized group and 32 ovulatory cycles in r-bmZP2-DT immunized group. Ovarian histopathology of both the immunized groups revealed the presence of atretic follicles with degenerated oocytes, which may have been the principle cause for the failure of immunized animals to conceive in spite of the decline in either ...
- Zonagen Suspends Further Research On Zona Pellucida Contraceptive Vaccine.
- Press release article from: Business Wire September 27, 2001 700+ words
...has suspended further research on a zona pellucida based contraceptive vaccine following...immunization with a primate recombinant zona pellucida protein. Though contraception was...published studies, a human recombinant zona pellucida immunocontraceptive vaccine consistently...
- Vam6P and SNAP involved in sperm-zona pellucida interactions.
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...Vam6P and SNAP are involved in sperm-zona pellucida interactions. According to a study...Antibodies to VAMP and SNAP inhibited sperm zona pellucida interaction, suggesting their possible...spermatozoa and their involvement in sperm-zona pellucida interactions. Biochem Biophys Res...
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- Magazine article from: The Biological Bulletin Silva, Celso P. Silva, Vanessa Kommineni, Karpura Keefe, David October 1, 1997 700+ words
The mammalian zona pellucida (zona) is composed of glycoprotein filaments organized in three layers that differ in their orientation and birefringence (1...
- Sperm protein may lead to male pill.(Brief Article)
- Magazine article from: Science News Travis, J. October 13, 2001 700+ words
...the layer around an egg, the zona pellucida," says Clapham. Finally...preventing them from penetrating the zona pellucida, Benoff contends. She doesn...says Tracy Rankin of the National Institute for Child Health and Development...
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- Press release article from: PR Newswire January 25, 1994 700+ words
...his research, including the National Institute of Child Health and Human...Health Science Center and the National Institute of Child Health and Human...technology relating to the zona pellucida, the protein-rich shell...
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- Press release article from: PR Newswire July 7, 1993 700+ words
...institutions including Merck, Sharp & Dohme, the National Institute of Health, Miles Laboratories and Bristol-Myers Squibb...its proprietary and patented technology relating to the zona pellucida, the protein-rich shell surrounding a mammalian egg...
- Study findings from P.A. Olsvik et al broaden understanding of hormones.(Report)
- Newspaper article from: Blood Weekly March 12, 2009 700+ words
...vitellogenin A (VtgA), vitellogenin B (VtgB), zona pellucida 2 (ZP2) (effects of estrogen disruptors), B-cell...For additional information, contact P.A. Olsvik, National Institute Nutrition & Seafood Research, N-5817 Bergen...
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...payments) inflation made by the National Institute for the period 1994Q1-2004Q4...fully. Accordingly since 1992Q3 the National Institute has, albeit in a sense implicitly...indicated the historical accuracy of National Institute forecasts by reporting the mean absolute...
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Source: HighBeam Research, E. coli-expressed zona pellucida glycoproteins have contraceptive...