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A-beta antibodies may prevent Alzheimer disease plaque formation.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Previous studies have shown that in various mouse models of Alzheimer's disease (AD), amyloid beta-protein (A-beta) antibodies generated by A-beta peptide immunization resulted in the prevention of A-beta plaque formation in brains of young mice, decreased A-beta plaque burdens in older mice and improved cognition. The purpose of this study was to optimize A-beta immunization protocols for future trials in transgenic mouse models of AD."
"The timing and titers of A-beta antibody production, as well as epitope(s) and immunoglobulin isotypes, were compared between two different mouse strains (C57BL/6 and B6D2F1) and five treatment protocols: (1) chronic A-beta nasal administration, (2) repeated A-beta intraperitoneal (i.p.) injection, (3) one i.p. injection followed by chronic A-beta nasal administration, (4) chronic and concurrent A-beta nasal administration + A-beta i.p. injection, and (5) untreated controls," reported Edward T. Spooner and collaborators at Harvard Medical School. "B6D2F1 mice generated A-beta antibodies earlier and in higher quantities than the C57BL/6 mice, indicating that B6D2F1 mice are more responsive to A-beta immunization. For both strains, mice that received the combination of A-beta nasal + A-beta i.p. injection showed the highest antibody titers."
The researchers continued, "Epitope mapping ...
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Source: HighBeam Research, A-beta antibodies may prevent Alzheimer disease plaque formation.