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Interleukin 21 prevents IgE production in mice.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from Japan and the United States, "Interleukin 21 (IL-21) has recently been identified as a multifunctional cytokine that induces the proliferation of T cells and B cells and differentiation of natural killer cells. To determine whether IL-21 regulates IL-4-mediated immune responses, we examined the effect of IL-21 on antigen-specific IgE production in mice. We also examined the effect of IL-21 on IL-4-induced IgE production from B cells and antigen-induced T-helper 2 (Th2) cell differentiation."
"The in vivo injection of IL-21 prevented antigen-specific IgE but not IgG2a production on immunization," reported Akira Suto and collaborators at Chiba University School of Medicine in Japan and ZymoGenetics, Inc. in the United States. "IL-21 did not affect Th2 cell differentiation or IL-4 production from CD4+ T cells but directly inhibited IL-4-induced IgE production from B cells at single-cell levels. Moreover, IL-21 inhibited IL-4-induced germ line C[subscript]epsilon transcription in B cells without the inhibition of signal transducer and activator of transcription 6 (Stat6) activation."
Suto ...
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...5]/0.2 ml/well) with IL-4 (1000 U/ml), IL-10 (100 ng/ml), anti...total IgE and latex-specific IgE production was measured as previously reported...days, and measured production of IL-4, IL-10, IL-12, IL...
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...effect. IL-21 has also been recognized for its ability to suppress IL-4-induced IgE production by murine B cells. Here, we identified IL-21 as an inducer of IgE production by CD40L-stimulated human naive B cells. Furthermore, there was...
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...Interleukin (IL)-21 downregulates...immunoglobulin E (IgE) production in murine systems...Research). "IL-21 dramatically enhanced IgE production by human mononuclear...signaling. Thus, IL-21 is a strong inducer of IgE production in human beings...
