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Antibody levels remain high in macaques given Quil A-adjuvanted measles vaccine.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from the Netherlands, "Quil A-based candidate measles vaccines have been shown to be immunogenic and protective in cotton rats and macaques. Here we studied the longevity of protective VN antibody levels induced in macaques with one dose of measles virus (MV) iscom. Inactivated MV adjuvanted with iscom-matrix or with purified Quillaja saponin QA-22 were also tested."
"All animals developed high levels of VN antibody and MV-specific IFN-gamma-producing cells," reported Koert J. Stittelaar and colleagues at the Institute of Virology at Erasmus MC in Rotterdam and the National Institute of Public Health and the Environment in Bilthoven. "Especially the high VN antibody levels induced by the latter two preparations showed virtually no decrease during the 2-year follow-up."
Stittelaar and coauthors concluded, "These highly promising candidate MV vaccines should now be tested in infant macaques in the presence or absence of passively transferred ...
- Antibody levels remain high in macaques given Quil A-adjuvanted measles vaccine.
- Newspaper article from: Virus Weekly February 11, 2003 700+ words
...of protective VN antibody levels induced in macaques...Especially the high VN antibody levels induced by the latter...Longevity of neutralizing antibody levels in macaques vaccinated...Quil A-adjuvanted measles vaccine candidates. Vaccine...
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- Measles Vaccine Rash.(Pediatric Advisor 2004.1)
- Clinical Reference Systems Schmitt, B.D. January 1, 2004 700+ words
What is the measles vaccine? The live measles vaccine has prevented many deaths and serious complications...given to children over 12 months of age. What is a measles vaccine rash? About 20% of children develop some mild symptoms...