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Adenovirus vectors effectively deliver MHC class I and II antigens.
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "Dendritic cells (DCs) are highly specialised antigen-presenting cells (APCs) that are essential for the initiation and modulation of T cell-mediated immune responses," according to recent research from England. "In order to induce effective CTL responses against most infections and tumors, DCs must prime both CD4+ and CD8+ antigen-specific T cells."
"It is, therefore, important in vaccine design to produce antigen-delivery systems that lead to the simultaneous presentation of multiple histocompatibility complex (MHC) class I- and class II-restricted antigenic peptides by DCs," explained O. B. Herrera and coauthors, University of London Imperial College of Science, Technology and Medicine.
Herrera and colleagues reported that "the infection of immature mouse bone marrow-derived DCs (BMDCs) with recombinant adenovirus (rAd) vectors led to a marked upregulation of surface costimulatory molecules, IL-12 p40 production and capacity to stimulate both allogeneic and antigen-specific T cells."
"Furthermore, infection of immature and mature BMDCs with a rAd encoding chicken ovalbumin (OVA) led to presentation of the antigen to TCR-transgenic OVA-specific CD4+ and CD8+ T cells," study data showed. "In addition, the activation state of responding CD8+ T cells was further amplified if they recognised antigen on rAd-transduced BMDCs in the presence of antigen-specific CD4+ T cells."
"The results suggest that rAd-encoded OVA protein is secreted ...
- Adenovirus vectors effectively deliver MHC class I and II antigens.
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...was able to deliver an OVA epitope for MHC class I presentation in dendritic cells (DCs...b-restricted epitope SIINFEKL for MHC class I presentation. However, delivery of...superscript]b-restricted epitope for MHC class II presentation occurred when E. coli...
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...was able to deliver an OVA epitope for MHC class I presentation in dendritic cells (DCs...b-restricted epitope SIINFEKL for MHC class I presentation. However, delivery of...superscript]b-restricted epitope for MHC class II presentation occurred when E. coli...
Source: HighBeam Research, Adenovirus vectors effectively deliver MHC class I and II antigens.