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Carbohydrate-based particles are better adjuvant than alum for allergy vaccines.(Brief Article)
2003 FEB 12 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Carbohydrate-based particles (CBP) acted as an effective adjuvant for the major timothy grass pollen allergen without causing the granulomatous tissue reaction produced by the commonly used adjuvant, alum, according to a report in the journal, Immunology.
"The occurrence of systemic anaphylactic side-effects in the course of allergen-specific immunotherapy has been strongly reduced by the adsorption of allergens to aluminum hydroxide, the most frequently used adjuvant in humans," said Hans Gronlund and colleagues at the Karolinska Institutet in Stockholm, Sweden, and the University of Vienna in Austria. "Using the major timothy grass pollen allergen, Phl p 5b, in its recombinant form for immunization of mice, we demonstrate that carbohydrate-based particles exhibit several potential advantages over aluminum-hydroxide as adjuvant for immunotherapy. "
Experiments in mice demonstrated that Phl p 5b bound to CBP was more immunogenic than unbound Phl p 5b (Carbohydrate-based particles: A new adjuvant for allergen-specific immunotherapy. Immunology, 2002;107(4):523-529).
"The antibodies induced by CBP-bound rPhl p 5b, exhibited potentially beneficial activities as they cross-reacted with group 5 allergens from five other grass species and inhibited the binding of grass pollen allergic patients IgE to Phl p 5b," reported Gronlund and his collaborators.
Elevated IgG1 antibody levels and increased production of interleukin-4 (IL-4) and interleukin-5 (IL-5) occurred in cultured ...
- Carbohydrate-based particles are better adjuvant than alum for allergy vaccines.
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Source: HighBeam Research, Carbohydrate-based particles are better adjuvant than alum for...