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Donor immunization may lower pneumococcal infection risk.(Brief Article)
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Immunization of hematopoietic stem cell donors may help prevent pneumococcal infections in transplant recipients, according to researchers in the United States.
"Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk for infections with Streptococcus pneumoniae and have long-lasting, impaired antibody responses to pneumococcal polysaccharide vaccines," explained Deborah C. Molrine and colleagues at the University of Massachusetts in Jamaica Plain, the Dana-Farber Cancer Institute and Brigham and Women's Hospital in Boston, and St. Davids, Pennslyvania-based Wyeth Pharmaceuticals.
Donor immunization with a pneumoccal conjugate vaccine improved vaccine-induced humoral activity in stem cell graft recipients, Molrine and coauthors found.
The researchers evaluated the utility of donor immunization with a heptavalent pneumococcal conjugate vaccine (PCV7) in a group of 96 stem cell donor-recipient pairs. Graft recipients were inoculated with PCV7 three times at three-month intervals after transplantation, with donors randomized to PCV7 or no vaccination, according to the report.
After the first and second posttransplant PCV7 inoculations, patients who received stem cells from immunized donors ...
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Source: HighBeam Research, Donor immunization may lower pneumococcal infection risk.(Brief...