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CHO cell clustering does not correlate with histamine-sensitization for pertussis toxin.(Brief Article)
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Chinese hamster ovary (CHO) cell clustering test failed to detect a reversion to pertussis toxin (PT) toxicity of a commercial diphtheria, tetanus, and pertussis (DtaP) vaccine batch that failed to pass the test for reversion to histamine sensitizing (HS) activity. Efficacy of CHO cell clustering assay was, accordingly, evaluated using purified PT treated with graded concentrations of formaldehyde at 37 degrees C for 24 hours."
"The formaldehyde-treated PT was shown to lose CHO cell clustering activity to the level of 0.01% by the mild treatment while retaining 3.7-20.3% of HS activity which were far over the levels of commercial vaccines," reported Michiyo Kataoka and colleagues at the National Institute of Infectious Diseases in Tokyo. "When a reversion to toxicity of the aldehyde-detoxified PT was examined by incubating at 37 degrees C for 3 weeks, CHO cell clustering test again failed to detect the reversion to toxicity of the PT which showed a remarkable reversion to HS activity."
Kataoka and coauthors ...
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