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Major Japanese cedar pollen antigens retain immunogenicity in a linked peptide.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "It has been demonstrated in detail that administration of a dominant T-cell determinant to animals induces activation or immunological tolerance of T cells. However, it has not been determined whether multiple T-cell determinants, when integrated into a single peptide, retain their potential to induce T-cell activation and tolerance. We prepared a synthetic peptide comprising three T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen antigens, and investigated the immunogenicity and tolerogenicity of each T-cell determinant in the linked peptide by means of lymph node cell proliferation assays using mice," researchers in Japan report.
"Lymph node cells from mice immunized with each of the three T-cell determinants proliferated against the linked peptide in a dose-dependent manner, similar to that of the immunized peptide," said Tomomi Yoshitomi and collaborators at Sankyo Company, Ltd, Hayashibara Biochemical Laboratories, Inc., the Jikei University School of Medicine, and the National Institute of Infectious Diseases.
They continued: "Lymph node cells from mice immunized with the linked peptide proliferated against all of the three T-cell determinants. In addition, the degree of proliferation against the three T-cell determinants occurred according to their original immunogenicity, as observed ...
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Source: HighBeam Research, Major Japanese cedar pollen antigens retain immunogenicity in a...