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DC-SIGN is an efficient target for delivery of T cell epitopes for MHC class II presentation.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Norway, "In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that efficiently channel the antigen into endocytic compartments for loading of MHC molecules. Antibodies have been used to deliver antigen; however, it is important to define optimal targets on antigen-presenting cells (APC) for efficient delivery."
"For this purpose, we have established a T cell readout that can be used to screen large numbers of different mAb for their ability to load MHC class II molecules," reported Karoline W. Schjetne and coauthors at the University of Oslo. "The novel human CD4(+) T cell clone is specific for mouse Ig C[subscript]kappa (40-48) and restricted by HLA-DR4 (DRA1,B1*0401). DR4 apparently presents both mouse and human C-kappa 40-48, but there is no cross-reaction at the T cell level. B cells from DR4 transgenic mice spontaneously process and present the mouse C[subscript]kappa peptide. The mouse C[subscript]kappa-specific T cell readout was used to demonstrate that mouse mAb specific for human dendritic cell (DC)-specific ICAM-grabbing non-integrin (DC-SIGN), a novel DC-specific molecule, were 10- to 1000-fold more potent at inducing kappa-specific human CD4(+) T ...
- Exosomes transfer functional MHC class I/peptide complexes to dendritic cells.
- Newspaper article from: Immunotherapy Weekly April 28, 2004 700+ words
...eradication. Because DC can secrete MHC class I-bearing exosomes...peptides could subserve the DC function consisting in MHC class I-restricted, peptide...study, we show that: DC release abundant MHC class I/peptide complexes...
- Hepatitis C virus persistence may depend on MHC class I interference.
- Newspaper article from: Hepatitis Weekly December 8, 2003 700+ words
...preventing the assembly of MHC class I molecules. This results...accumulation of unfolded MHC class I. Therefore, the persistence...mediated interference of MHC class I assembly and cell surface...N St. NW, Washington, DC 20036-2904, USA. The...
- Beta cell MHC class I is a late requirement for diabetes.
- Newspaper article from: Health & Medicine Week August 4, 2003 700+ words
...NewsRx.net) -- Beta cell MHC class I is a late requirement...between these cells and MHC class I on the beta cells has...Sciences USA (Beta cell MHC class I is a late requirement...Avenue NW, Washington, DC 20418, USA. The information...
- Hepatitis C upregulation of MHC class I impairs natural killer cell activity.
- Newspaper article from: Genomics & Genetics Weekly September 12, 2003 700+ words
...Hepatitis C upregulation of MHC class I impairs natural killer...histocompatibility complex (MHC) class I upregulation." "Moreover...consequence of increased MHC class I expression, a significantly...St. NW, Washington, DC 20036-2904, USA. The...
- MHC class I-restricted alloreactive CD4 T cells identified.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...NewsRx.com & NewsRx.net) -- A set of MHC class I-restricted alloreactive CD4 cells has been...recognize major histocompatibility complex (MHC) class II molecules, MHC class I-reactive CD4+ T cells have occasionally...
- Aberrant MHC class II expression not sufficient to induce thyroid autoimmunity.
- Newspaper article from: Immunotherapy Weekly June 30, 2004 700+ words
...com & NewsRx.net) -- Aberrant MHC class II expression alone is not sufficient...of major histocompatibility complex (MHC) class II molecules on thyrocytes has been demonstrated...However, the role of this aberrant MHC class II in disease development is controversial...
- Ii-Key/MHC class II epitope hybrid peptide vaccines show promise for HIV.
- Newspaper article from: AIDS Vaccine Week January 26, 2004 700+ words
...com & NewsRx.net) -- Ii-Key/MHC class II epitope hybrid peptide vaccines show promise...research from the United States, "The Ii-Key/MHC class II epitope hybrid acts on MHC class II molecules to facilitate replacement of antigenic...
- HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy.
- Newspaper article from: Cancer Weekly April 8, 2003 700+ words
...effective in mice carrying HPV16-associated, MHC class I+ tumors than in those carrying and class...examined in mice carrying HPV16-associated, MHC class I+ (TC-1), and MHC class P (MK16) tumors. Intraperitoneal treatment...
