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Glial cells play a role in defense against herpesvirus infections.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Glial cells can respond to herpesvirus infections through the production of cytokines and chemokines. Although specific interactions between resident glia and lymphocytes that infiltrate the infected brain remain to be defined, the presence of T cell chemotactic signals in microglial cell supernatants following infection with cytomegalovirus or herpes simplex virus has led to the concept that chemokines initiate a cascade of neuroimmune responses that result in defense of the brain against herpesviruses."
"While chemokines may play a defensive role by attracting T cells into the brain, aberrant accumulation of lymphocytes may also induce brain damage," reported James R. Lokensgard and collaborators at the Minneapolis Medical Research Foundation. "Host defense mechanisms must balance control of herpesvirus spread with associated undesirable immunopathologic effects."
The researchers concluded, "A growing body of evidence suggests that through complex ...
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Source: HighBeam Research, Glial cells play a role in defense against herpesvirus infections.