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Researchers investigate gene expression during maturation of immature dendritic cells.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Dendritic cells (DCs) are the most important antigen-presenting cells. Many recent studies have compared the function of immature DCs (iDCs) and mature DCs (mDCs), but there have been few reports of the molecular changes that occur in DCs during maturation. Here, we report on differential gene expression in iDCs generated from peripheral blood monocytes compared with mDCs."
"Gene expression was evaluated using the differential display method after activation of iDCs with a low concentration of lipopolysaccharide (LPS) to induce maturation," said T. Matsunaga and colleagues at Sapporo Medical University and the University of Tokyo. "Proteasome subunit alpha type 3 (PSMA3), transcription factor EC (TFEC) isoform, and BTK region clone 2f10-rpi were transiently upregulated. Tryptophanyl-tRNA synthetase and CD63 antigen were upregulated for at least 24 hours. Neuronal apoptosis inhibitory protein (NAIP) and transforming growth factor-beta-induced 68 kDa protein were downregulated."
The researchers concluded, "This is the first report of NAIP expression in human DCs. By comparing the ...
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