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Human cytomegalovirus genomes highly divergent.(Brief Article)
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Italy, "The low-passage Toledo strain of human cytomegalovirus (HCMV) and fresh clinical HCMV isolates have been reported to share the capacity to propagate efficiently in endothelial cell cultures.
"In the laboratory, however, repeated attempts to adapt the Toledo strain to growth in endothelial cells have been unsuccessful. Southern blot analysis of the entire viral genome and restriction length polymorphism analysis of multiple genome regions amplified by PCR demonstrated that the reported endothelial cell-tropic viral variant of the Toledo strain and the parental Toledo strain are highly divergent."
"In fact, the restriction profile of the genome of the endothelial cell-tropic variant seems highly distinct from that of the parental strain," stated Fausto Baldanti and collaborators at IRCCS Policlinico San Matteo.
Baldanti and coauthors concluded that "the degree of dissimilarity between the two genomes ...
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Source: HighBeam Research, Human cytomegalovirus genomes highly divergent.(Brief Article)