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Dendritic cell vaccine shows promise against EBV-positive nasopharyngeal carcinoma.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a team of researchers from Taiwan, the People's Republic of China, and England, "Nasopharyngeal carcinoma (NPC), a common neoplasm in Southeast Asia, is EBV-positive and expresses a limited number of antigens, including latent membrane protein 2. In this study, autologous monocyte-derived dendritic cells were cultured from patients with advanced NPC, matured with cytokine, pulsed with HLA-A1101-, A2402-, or B40011-restricted epitope peptides from EBV latent membrane protein 2 and injected into inguinal lymph nodes."
"Sixteen patients with local recurrence or distant metastasis after conventional therapies received four injections at weekly intervals," said Chen-Lung Lin at Chang Gung Memorial Hospital in Kaohsiung, Taiwan and colleagues. "Epitope-specific CD8+ T-cell responses were elicited or boosted in 9 patients receiving HLA-A1101- or A2402-restricted peptides, with stronger responses seen to the A1101 peptide. Furthermore, epitope-specific cytotoxicity was detectable in peripheral blood T cells harvested at 3-months after vaccination from A1101-responsive patients, ...
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Source: HighBeam Research, Dendritic cell vaccine shows promise against EBV-positive...