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Mannose-binding lectin genotype determines lectin levels and function.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Australia, "The mannose-binding lectin (MBL) pathway of complement activation is an important component of innate host defense. Numerous studies have described associations between the MBL genotype, MBL levels and disease susceptibility. However, genotyping and quantitative assays used in these studies have frequently been limited, and comprehensive data examining the interaction between structural and coding MBL genetic variants, MBL antigenic levels, and MBL functional activity are lacking."
"Such data may be important for accurate planning and interpretation of studies of MBL and disease," said R. M. Minchinton and collaborators at the Cooperative Research Centre for Vaccine Technology at the Australian Red Cross Blood Service. "This study has examined MBL in a cohort of 236 Australian blood donors. Five MBL promoter and coding single nucleotide polymorphisms were genotyped using polymerase chain reaction-sequence-specific priming (PCR-SSP). Plasma levels of MBL antigen were quantified using a double-antibody enzyme-linked immunosorbent assay (ELISA), and functional MBL levels were quantified using a mannan-binding assay. Activation of the complement pathway by MBL was measured in a C4-deposition assay."
The researchers concluded, ...
- Mannose-binding lectin genotype determines lectin levels and function.
- Newspaper article from: Immunotherapy Weekly February 5, 2003 700+ words
...The mannose-binding lectin (MBL) pathway...their study in the Scandinavian Journal of Immunology...between mannose-binding lectin (MBL) genotype...subscribe to the Scandinavian Journal of Immunology...
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- Newspaper article from: Proteomics Weekly September 1, 2003 700+ words
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- Newspaper article from: Immunotherapy Weekly June 4, 2003 700+ words
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- Newspaper article from: Hepatitis Weekly May 12, 2003 700+ words
...amp; NewsRx.net) -- Mannan-binding lectin doesn't correlate with vulnerability...disproportionately conferring low mannan-binding lectin (MBL) concentrations. Our aims were...Experimental Immunology (Mannan-binding lectin and hepatitis C infection. Clin Exp...
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- Newspaper article from: TB & Outbreaks Week January 6, 2004 700+ words
...amp; NewsRx.net) -- Mannose-binding lectin (MBL) polymorphisms providing for...Diseases (Association of mannose-binding lectin polymorphisms with sepsis and fatal...Inflammatory Response Syndrome, Mannose-Binding Lectin, Genetics and Genomics, Gene Polymorphisms...
