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New model of yeast pathogenesis developed.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to researchers in the United States, "We found that the well-studied nematode Caenorhabditis elegans can use various yeasts, including Cryptococcus laurentii and Cryptococcus kuetzingii, as a sole source of food, producing similar brood sizes compared with growth on its usual laboratory food source Escherichia coli OP50."
"C. elegans grown on these yeasts had a life span similar to (C. laurentii) or longer than (C. kuetzingii) those fed on E. coli," reported Eleftherios Mylonakis and collaborators at Massachusetts General Hospital, Harvard Medical School, and Duke University Medical Center. "However, the human pathogenic yeast Cryptococcus neoformans killed C. elegans, and the C. neoformans polysaccharide capsule as well as several C. neoformans genes previously shown to be involved in mammalian virulence were also shown to play a role in C. elegans killing. These included genes associated with signal transduction pathways (GPA1, PKA1, PKR1, and RAP), laccase production (LAC1), and the alpha mating type. C. neoformans adenine auxotrophs, which are less virulent in mammals, were also less virulent in C. elegans."
Mylonakis and coauthors concluded, "These results support the ...
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Source: HighBeam Research, New model of yeast pathogenesis developed.