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Efficacy of edible vaccines must be tested by eating.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from The Netherlands, "To evaluate whether vaccine administration via intragastric gavage is indicative for the outcome of edible vaccines, mice were orally immunized with ovalbumin (OVA) mixed with or without Vibrio cholerae toxin (CT) in various compositions via various routes: * OVA dissolved in saline and intragastrically (IG) administered ('IG');
* OVA mixed with food extract and administered IG ('food IG');
* food chow absorbed with OVA dissolved in saline and fed to the animals ('food'); and
* OVA dissolved in saline and administered via drinking bottles ('drinking')."
"When given to naive mice, 'IG' and 'food IG' but not 'food' or 'drinking' induced anti-OVA IgG1 responses in serum, but oral boost immunizations were necessary. Serum IgA was not induced," the study said.
"Oral boosting of subcutaneously (SC) primed mice enhanced the IgG1 and IgA response in serum regardless of the route of immunization or the vaccine composition," reported Tosca G. M. Lauterslager and Luuk A. T. Hilgers at the Free University of Amsterdam. "CT did not dramatically enhance the immune response. All immunization routes except 'drinking' induced antigen-specific IgA antibody secreting cells (ASC) in the lamina propria of naive mice. But antigen-specific antibody ...
- FILIPINO SCIENTISTS SEEKING TO CREATE "EDIBLE VACCINES".
- News wire article from: Asia Africa Intelligence Wire September 9, 2005 700+ words
...collaborating in preparing these "edible vaccines." These plant molecular...welcome the possibilities of edible vaccines in the next three to five...trials on plant-derived edible vaccines are already underway in some...
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- News wire article from: Europe Intelligence Wire February 15, 2005 700+ words
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- Researchers Advance Toward Turning Tomatoes Into Source of Low-Cost Treatments,...
- News wire article from: Ascribe Higher Education News Service April 8, 2002 700+ words
...developing tomatoes as a possible source of edible vaccines and other proteins such as therapeutic...then be purified from the fruit. For edible vaccines, a different gene - one from the...needles," Ewing says. "While the edible vaccines would still need to be administered...
- ProdiGene Receives Patent for Edible Vaccines for Viral Diseases.
- Press release article from: PR Newswire July 20, 1999 700+ words
...their human and animal populations. "Edible vaccines have several advantages," Dr. Howard...several diseases." Most oral or edible vaccines have been cost-prohibitive in the...stringent purification. But the ProdiGene edible vaccines would be grown in plants that are...
- Edible Vaccines.(cure in some transgenic plants)(Brief Article)
- Magazine article from: The Futurist September 1, 2001 700+ words
...carry a vaccine to fight measles, offering the prospect of edible vaccines. The technique may also be applied to protecting a range...plants that humans eat, such as rice and lettuce. The edible vaccines would be ideal for use in baby food, Wesselingh believes...
- ProdiGene is First to Demonstrate Vaccination With Edible Vaccines.
- Press release article from: PR Newswire February 15, 2000 700+ words
...ProdiGene vice president of product development. "Edible vaccines will give pork producers several distinct benefits," Dr...vaccines. "Perhaps the most important benefits are that edible vaccines will be less expensive and easier to administer," Jilka...
- Mycogen Obtains Human and Animal Health Rights For Genetically Altered Plants...
- Press release article from: PR Newswire November 3, 1997 700+ words
...technology to genetically alter plants to produce and deliver edible vaccines. The licenses grant Mycogen exclusive rights under broad...on the idea of genetically engineering plants to become edible vaccines. After further study and experiments, they filed a patent...
- Edible vaccines.(Hepatitis B vaccine via lettuce)(Brief Article)
- Magazine article from: The Food Institute Report October 15, 2001 700+ words
* Edible vaccines, produced from fruits and vegetables, are expected to be available within a decade, according to vaccine researcher Dr. Alexander...
- VACCINES AND ANTI-INFECTIVES Edible Vaccines Win Patent.
- Newspaper article from: Applied Genetics News August 1, 1999 700+ words
...marketed either in edible form-- made from fruit, vegetable, or grain products-or used in injectable form. Oral or edible vaccines have been cost-prohibitive, in part, because the Food and Drug Administration (FDA) requires stringent purification...
- Edible vaccines on the way.(Brief Article)
- Newspaper article from: The BBI Newsletter June 1, 2000 700+ words
Annick Mercenier and her team at Transgene (Strasbourg, France) have been investigating the possibility of using lactic acid bacteria (LAB) as candidates for oral vaccines and drug delivery vehicles. Their initial basic scientific research has confirmed that a number of LAB could be used as vaccine
Source: HighBeam Research, Efficacy of edible vaccines must be tested by eating.