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Combining dendritic cells and CpG oligodeoxynucleotides cures colon cancer in mice.
2003 FEB 5 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Large murine colon carcinoma tumors were eliminated in mice co-injected with mature antigen-pulsed dendritic cells (DCs) and CpG oligodeoxynucleotides (CpG ODN), according to a report in the European Journal of Immunology.
"The use of dendritic cells (DC) loaded with tumor antigen is one of the most advanced approaches in cancer immunotherapy," said Klaus Heckelsmiller and colleagues at Ludwig-Maximilians-University of Munich and the University of Kiel in Germany. "CpG motifs within microbial DNA detected by toll-like receptor 9 are responsible for the favorable properties of CpG oligodeoxynucleotides (ODN) as immune modulators."
However, the researchers found that vaccines consisting of either antigen-pulsed DCs or CpG ODN, while effective against small (less than 1 cm in diameter) tumors, were not effective against larger ones. Therefore, Heckelsmiller and his collaborators combined the treatments to determine the effect against larger, established murine tumors.
"Rejection of large tumors and long-term cure of mice was achieved by combining injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with peritumoral injections of CpG ODN," reported the investigators.
DCs positive for DEC-205 infiltrated the tumor in large numbers in vaccinated mice. However, the efficacy of the treatment could be terminated by ...
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