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Inhibitor Id2 needed for mammary cell differentiation in pregnancy.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- Without the helix-loop-helix protein inhibitor of differentiation Id2, breast cells won't undergo differentiation like they should during pregnancy, researchers say.
"Mammary alveolar development during pregnancy is triggered by hormone signals. The prolactin receptor/Jak2/signal transducer and activator of transcription (Stat) 5 signal transduction pathway is the principal mediator of these cues and alveolar development is abrogated in its absence. The loss of the basic helix-loop-helix protein inhibitor of differentiation (Id)2 results in a similar defect," researchers in the United States wrote.
"To investigate the role of Id2 in mammary epithelium, we performed structural and molecular analyses. Id2-null mammary epithelial cells were unable to form alveoli; the epithelial architecture was disorganized and dissimilar from early stages of alveologenesis in wild-type glands. The epithelial cells retained the ductal marker Na-K-Cl cotransporter (NKCC)1," said K. Miyoshi and colleagues, National Institutes of Health, NIDDKD, Laboratory for Genetics and Physiology.
"Nuclear localization of Stat5a and down-regulation of NKCC1 was observed in some areas, indicating a limited response to pregnancy signals. The differentiation status of Id2-null tissue at ...
- In-vitro adherence of candida albicans to conjunctival epithelial cells of...
- Magazine article from: Indian Journal of Ophthalmology Bhardwaj, Gabu Vashist, Shashi Khan, Imtiaz July 1, 1985 700+ words
...adherence of C. albicans to conjunctival epithelial cells compared to conjunctional cells from...were involved. Human conjunctival epithelial cells : Eyes were first anaesthetized by...test : 0.5ml samples of yeast and epithelial cells (ratio of yeast to epithe-lial...
- Mammary epithelial cells express the osteopontin mediator Runx2.
- Magazine article from: Women's Health Weekly January 15, 2004 700+ words
...amp; NewsRx.net) -- Mammary epithelial cells express the osteopontin mediator Runx2...cell lines and in primary mammary epithelial cells. In addition, we have also found...Osteopontin (OPN) is expressed in mammary epithelial cells during pregnancy and lactation and...
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...diisocyanate (HDI) on human airway epithelial cells at the cellular and molecular level...binding and uptake by human airway epithelial cells and begin to identify genes that may...4). The effects of HDI on airway epithelial cells remain poorly described despite the...
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- Newspaper article from: Drug Week July 30, 2004 700+ words
...NewsRx.net) -- Iris pigment epithelial cells show promise as neurotrophic gene...candidates. As also fetal retinal pigment epithelial cells have been successfully tested for...investigated the potential of iris pigment epithelial cells as an autologous source for future...
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...whether human conjunctival epithelial cells (HCECs) express functionally...using Chang conjunctival epithelial cells as in vitro model. We performed...Furthermore, ocular epithelial cells are active participants...
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...production of rat endometrial epithelial cells in a concentration-dependent manner...and enzyme activity in endometrial epithelial cells may be involved in the inhibitory...the endometrial: stromal cells and epithelial cells. A study showed that epithelial cells...
- Polarized epithelial cells sensitive to the pore-forming toxin aerolysin.
- Newspaper article from: TB & Outbreaks Week April 1, 2003 700+ words
...amp; NewsRx.net) -- Polarized epithelial cells sensitive to the pore-forming toxin...pore in the plasma membrane. "Since epithelial cells of the intestine are the primary targets...effect on three types of polarized epithelial cells: Caco-2 cells, derived from human...
- Expression and secretion of CXCL-8 and CXCL-10 from Mycobacterium bovis...
- Magazine article from: Mediators of Inflammation Mendez-Samperio, Patricia Miranda, Elena Vazquez, Abraham January 1, 2006 700+ words
...4 on chemokine production by human epithelial cells infected with Mycobacterium bovis...in M. bovis BCG-infected human epithelial cells, CXCL-8 mRNA level was significantly...that M. bovis BCG-infected human epithelial cells can have an active role in a local...