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New murine model enables study of growth factor in gynecological cancer.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers have established a new murine model that improves the study of ovarian cancer.
"Vascular endothelial growth factor (VEGF) performs multifaceted functions in the tumor microenvironment promoting angiogenesis, suppressing antitumor immune response, and possibly exerting autocrine functions on tumor cells. However, appropriate syngeneic animal models for in vivo studies are lacking. Using retroviral transfection and fluorescence-activated cell sorting, we generated a C57BL6 murine ovarian carcinoma cell line that stably overexpresses the murine VEGF164 isoform and the enhanced green fluorescent protein," reported researchers from the United States.
"VEGF164 overexpression dramatically accelerated tumor growth and ascites formation, significantly enhanced tumor angiogenesis, and substantially promoted the survival of tumor cells in vivo. In vitro, VEGF164 overexpression significantly enhanced cell survival after growth factor withdrawal and conferred resistance to apoptosis induced by cisplatin through an autocrine mechanism," noted L. Zhang and colleagues, University of Pennsylvania, Center for Research on Reproduction and Women's Health.
"VEGF/green fluorescent protein-expressing tumors were not recognized by the adaptive immune system. After vaccination, a ...
- Depression of salivary epidermal growth factor by smoking.
- Magazine article from: British Medical Journal Jones, P.D.E. Hudson, N. Hawkey, C.J. February 22, 1992 700+ words
...are, however, unclear. Epidermal growth factor is a polypeptide secreted into saliva...shown that output of salivary epidermal growth factor is diminished in patients with rheumatoid...with reduced secretion of epidermal growth factor. Patients, methods, and results...
- Cancer and insulin-like growth factor-I: a potential mechanism linking the...
- Magazine article from: British Medical Journal Smith, George Davey Gunnell, David Holly, Jeff October 7, 2000 700+ words
...environment with cancer risk Insulin-like growth factor-I acts as an important mediator between...proteins. The role of insulin-like growth factor-I in promoting cancer has been investigated...associations between insulin-like growth factor-I and prostate cancer, premenopausal...
- Hepatocyte growth factor neutralization retards cutaneous wound healing.
- Newspaper article from: Angiogenesis Weekly March 28, 2003 700+ words
...amp; NewsRx.net) -- Hepatocyte growth factor neutralization retards cutaneous wound...elucidate biologic functions of hepatocyte growth factor and the c-Met receptor in cutaneous...expression and localization of hepatocyte growth factor and c-Met receptor and used a strategy...
- Insulin-like growth factor-I can be helpful towards end of life.(Brief...
- Magazine article from: British Medical Journal Bolger, Aidan Doehner, Wolfram Anker, Stefan D March 17, 2001 700+ words
...circulating concentrations of insulin-like growth factor-I to the risk of developing certain...the use of exogenous insulin-like growth factor-I by athletes, in whom the additional...apoptotic properties of insulinlike growth factor-I be should be considered in a different...
- Connective tissue growth factor may play role in formation.
- Newspaper article from: Gastroenterology Week January 27, 2003 700+ words
...United States, "connective tissue growth factor stimulates fibroblast proliferation...expression pattern of connective tissue growth factor in postoperative intra-abdominal...blotting for temporal connective tissue growth factor mRNA and protein expression, respectively...
- Growth factor predicts cancer's spread.
- Magazine article from: Science News Fackelmann, Kathy A. March 5, 1994 700+ words
...homing in on urinary concentrations of a growth factor involved in cancer's deadly spread...that a peptide called basic fibroblast growth factor could trigger the beneficial growth...p.71). The dark side of this growth factor, and others like it, is that they...
- Epidermal growth factor receptor and proliferating cell nuclear antigen in...
- Magazine article from: Neurology India Maiti, Arpan Ghosh, Keya Chatterjee, Uttara Chakrobarti, Sasanka Chatterjee, Sandip Basu, Samik October 1, 2008 700+ words
...involvement of various growth factors, growth factor receptors and proliferative markers...being studied extensively. Epidermal Growth Factor Receptor (EGFR) gene overexpression...various growth factors like Epidermal Growth factor (EGF), Platelet Derived growth ...
- Scientists at Technical University publish research in vascular endothelial...
- Newspaper article from: Angiogenesis Weekly April 24, 2009 700+ words
...biochemical properties of the transplant remain unanswered. Basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-BB have been...
- Octreotide prevents growth factor-dependent endothelial cell proliferation.
- Newspaper article from: Drug Week June 11, 2004 700+ words
...NewsRx.net) -- Octreotide prevents growth factor-dependent endothelial cell proliferation...factors, such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF)-1, basic fibroblast growth factor...
- Gene transfection of hepatocyte growth factor attenuates cardiac remodeling.
- Newspaper article from: Gene Therapy Weekly January 16, 2003 700+ words
...failure canine model. "Hepatocyte growth factor, a potent angiogenic agent, is unique...of gene transfection of hepatocyte growth factor on the failing heart. Four weeks after...pacing, either the human hepatocyte growth factor gene (160 microg; hepatocyte growth...
Source: HighBeam Research, New murine model enables study of growth factor in gynecological...