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Insulin sensitivity linked to visceral fat mass in premenopausal women.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Researchers in Canada found a strong association between visceral fat mass and insulin resistance in premenopausal women, according to a report in the Journal of Clinical Endocrinology and Metabolism.
Robert Ross and colleagues at Queen's University in Ontario examined the associations between insulin sensitivity and fat deposition and muscle composition in 40 abdominally obese, premenopausal women. The women underwent measurements for glucose disposal (euglycemic clamp studies), muscle composition (computed tomographic scans), fat mass (magnetic resonance imaging), and cardiovascular fitness level.
Even after controlling for subcutaneous fat mass, muscle attenuation, and maximum oxygen uptake, a significant inverse relation was found between glucose disposal rate and visceral fat (r=-0.42, p
"Subdivision of abdominal subcutaneous adipose tissue into anterior and posterior depots did not alter the observed relationships," reported Ross and his collaborators.
Among women with similar amounts of abdominal subcutaneous adipose tissue, those with high amounts of visceral adipose tissue had significantly lower glucose disposal rates compared to women with low amounts of visceral adipose tissue (p
Ross and his coauthors concluded that "visceral adipose tissue alone is a strong correlate of insulin resistance independent of nonabdominal, abdominal subcutaneous adipose tissue, muscle composition, and cardiovascular fitness. Subdivision of abdominal subcutaneous adipose tissue did not provide additional insight into the relationship between ...
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Source: HighBeam Research, Insulin sensitivity linked to visceral fat mass in premenopausal...