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Ergothioneine mitigates diabetic embryopathy in pregnant rats.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- According to recent research from groups in Spain and England, "The natural antioxidant ergothioneine (2-mercaptohistidine trimethylbetaine) is a fungal metabolite and found in most plant and animal tissues. The effect of ergothioneine on diabetic embryopathy in rats was assessed."
"Supplementation of diabetic pregnant rats with L-ergothioneine (1.147 mg/kg body weight) daily for the first 11.5 days of pregnancy reduced the rate of embryo malformations to values similar to the non-diabetic animals," said M. V. Guijarro and collaborators at the Imperial College of Science, Technology, and Medicine in London and the Universidad de San Pablo CEU in Madrid. "The ergothioneine had no effect on the plasma glucose levels, both in diabetic and control animals."
The researchers concluded that "the inhibition of the glucose-mediated free radical dependent embryo malformation by ergothioneine is an important antioxidant prophylactic mechanism, which when combined with vitamin E could ...
- Ergothioneine mitigates diabetic embryopathy in pregnant rats.(Brief Article)
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