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Cadmium absorption increases during pregnancy.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers say cadmium adsorption increases in pregnant female rats.
"Increased intestinal absorption of essential nutrients is characteristic of pregnancy as the maternal gastrointestinal tract undergoes physiological and biochemical changes to accommodate the increased demand for essential nutrients by the fetus. Divalent metal transporter-1 (DMT-1) is primarily responsible for dietary iron uptake in the duodenum but also recognizes nonessential metals such as cadmium (Cd). Increased absorption of Cd has been reported in pregnant compared with nonpregnant mice; however, the mechanism is not understood," researchers in the United States reported.
"The purpose of this work was to determine whether Cd absorption is increased in pregnant compared with nonpregnant rats and whether this correlates with a time-dependent up-regulation of DMT-1 expression."
"Timed pregnant and nonpregnant female Sprague-Dawley rats were administered Cd-109-labeled CdCl2 by oral gavage on gestation day (gd) 19. Tissues were collected on gd 20 for Cd-109 assessment (values expressed as pmol Cd)," explained T.M. Leazer and colleagues, University of Kansas, Medical Center.
"Greater accumulation of Cd-109 was observed in duodenum than in jejunum and ileum in both pregnant and nonpregnant rats. However, the amount of Cd in small intestine was higher in pregnant than nonpregnant rats. ...
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Source: HighBeam Research, Cadmium absorption increases during pregnancy.