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Cervical keratinocyte gene changes linked to human papillomavirus 16.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers have a new set of genes that associate with the integration of human papillomavirus 16 in cervical cancer cells.
According to recent research from England, "episomal integration is a critical event in human papillomavirus (HPV)-related oncogenesis, although little information is currently available concerning the effect of integration on the host transcriptome."
"We have used expression microarrays to investigate the effect of integration of HPV16 on gene expression in cervical keratinocytes, using the unique cell line model W12. W12 was generated from a cervical low-grade squamous intraepithelial lesion 'naturally' infected with HPV16 and at low passage contains approximately 100 HPV16 episomes/cell," stated W. Alazawi and colleagues, MRC/Hutchinson Research Center, Cambridge, UK.
"With passage in vitro, integration of viral episomes is associated with the development of phenotypic and genomic abnormalities resembling those seen in cervical neoplastic progression in vivo. We have used the Affymetrix U95A oligonucleotide array that contains probes for 12,600 human transcripts and have identified 85 genes from a range of host cell pathways that show changes in expression levels after integration of HPV16."
"Whereas some of the genes have previously been implicated in HPV-related oncogenesis in vivo, we have also identified a ...
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- Cervical keratinocyte gene changes linked to human papillomavirus 16.
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Source: HighBeam Research, Cervical keratinocyte gene changes linked to human papillomavirus 16.