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Research investigates progestin-mediated signaling in cancer cells.
2003 FEB 6 - (NewsRx.com & NewsRx.net) -- The authors of a new study have investigated progestin-mediated signaling in certain cancer cells.
"We have previously shown that the G protein-coupled receptor (GPR)30 is critical for progestin-induced growth inhibition. In this study, we addressed signal transduction pathways involved in progestin-mediated signaling. Progestin could not provide any additional growth inhibitory effect to MCF-7 cells treated with specific MAPK kinase inhibitors, PD98059 and U0126," said researchers in Finland.
"Medroxyprogesteroneacetate (MPA) induced a late (22-23 hour) decrease in ERK-1 and -2 activities verified by immunoblotting and kinase assay. The inactivation was abrogated by antiprogestin. Transient expression of GPR30 decreased ERK-1 and -2 activity; and in the cells in which GPR30 expression was decreased by the antisense, ERK activities were increased."
"The antisense-expressing cells were able to significantly resist the growth-inhibitory effect of the MAPK kinase inhibitors PD98059 and U0126 but not that of other factors tested. Interestingly, the decrease of ERK activity induced by MPA was abrogated by GPR30 antisense" wrote T.M. Ahola and colleagues, Tampere ...
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Source: HighBeam Research, Research investigates progestin-mediated signaling in cancer cells.