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New chemokines may have a role in vernal keratoconjunctivitis. (Echo).(Brief Article)
New attractants of T lymphocytes and several activation factors contribute to inflammation in vernal keratoconjunctivitis (VKC), a molecular study has found. The findings may help to explain how T lymphocytes are recruited to the conjunctiva.
Three chemokines--pulmonary and activation regulated chemokine (PARC), macrophage derived chemokine (MDC), and 1-309, the MDC receptor CCR4--strongly attractive to T lymphocytes were present in the cytoplasm of inflammatory cells in sections of conjunctivas from patients with VKC. PARC predominated, appearing in all specimens and in many more of the abundant CD3 + T lymphocytes in the upper substantia propria. MDC and 1-309 …
