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Color power Doppler sonography correlates with immunohistochemical analysis.(breast tumor measurement)
2003 JAN 16 - (NewsRx.com & NewsRx.net) -- M.D. Anderson Cancer Center diagnostic imaging specialists report that color power Doppler sonographic measurement of breast tumor vasculature, particularly in 3D, correlates with immunohistochemical analysis of microvessel density.
"Women with palpable breast masses scheduled for excision biopsy were scanned with two- and three-dimensional color power Doppler sonography before and after the administration of a sonographic contrast agent. Vessel counts were performed on two- and three-dimensional sonographic images before and after contrast agent administration. All tumors were surgically removed and underwent immunohistochemical analysis for microvessel density assessment. The sonographic measure of tumor vascularity was correlated with microvessel density," wrote W.T. Yang and colleagues.
"Pathologic examination showed 43 breast cancers and 14 benign breast masses. Higher microvessel density was noted in malignant than benign breast masses (p
They also observed "a significant positive correlation ... between microvessel density and the number of intratumoral blood vessels assessed by both two- and three-dimensional color power Doppler sonography (p
The researchers concluded: "A significant correlation was shown between color power Doppler sonographic measurement of tumor vascularity and microvessel density by immunohistochemical analysis. Further improvement in Doppler sonographic techniques to map capillary vessel flow should be explored to improve the current association with pathologic findings."
Yang and coauthors ...
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