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Intranasal vaccine generates antibody reaction in the genital tract.(contraceptive vaccine research)
2003 JAN 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing a human sperm surface antigen delivered intranasally stimulated production of antigen-specific IgA antibodies in the vaginas of mice.
"The common mucosal immune system has developed as a barrier for the numerous encounters between the host and various pathogens," explained A. Hasegawa and colleagues at Hyogo Medical University in Japan. "It is possible to exploit this system to induce secretion of IgA antibody which inhibits sperm penetration in the female genital tract."
The investigators formulated a vaccine containing a synthetic peptide matching the core peptide of the CD52 sperm surface antigen conjugated to diphtheria toxoid in DOTAP:cholesterol liposomes. The vaccine was administered to female mice intranasally, after which levels of IgA antibodies were measured in vaginal washes from the mice (Nasal immunization with diphtheria toxoid conjugated-CD52 core peptide induced specific antibody production in genital tract of female mice. American Journal of Reproductive Immunology, 2002;48(5):305-311).
The levels of IgA antibodies increased in the vaginal secretions of mice vaccinated with the CD52 antigen vaccine. Other antibody types specific to CD52 also increased in the serum after intranasal delivery of the vaccine.
Antibody titers rose to their highest levels after a booster vaccination given when initial antibodies titers dropped.
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Source: HighBeam Research, Intranasal vaccine generates antibody reaction in the genital...