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Gene re-expression tilts breast and ovarian cancer towards self-destruction.(ARHI tumor suppressor gene re-expression)
2003 JAN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cancer researchers say getting cancer cells to re-express the ARHI tumor suppressor gene encourages their self-destruction.
According to medical investigators at the University of Texas M.D. Anderson Cancer Center, ARHI shares some similarity with ras and rap genes but behaves differently. ARHI activity is limited in ovarian and breast cancer cells, but its overexpression leads to increased programmed cell death, or apoptosis. Cancer center researchers have identified the pathways leading to ARHI gene-induced apoptosis.
Several assays performed by Jia-Ju Bao and colleagues showed adenovirus-based transfer of ARHI led to increased apoptosis in up to 45% of breast cancer cells and 11% of ovarian cancer cells within a week of their being treated.
Although investigators detected one apoptosis marker, poly(ADP-ribose) polymerase, in the control centers of cells that underwent apoptosis, they could not detect the activity of several effector caspases (Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Cancer Research, 2002;62(24):7264-7272).
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Source: HighBeam Research, Gene re-expression tilts breast and ovarian cancer towards...