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Lispro comparable with regular insulin for use during pregnancy in type 1 diabetic women.
2003 JAN 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Rapid-acting lispro insulin therapy performed as well as regular short-acting insulin in women with pregnancies complicated by type 1 diabetes, according to a report in Diabetes Research and Clinical Practice.
B. Persson and colleagues at Karolinska Hospital, Huddinge University Hospital, and Uppsala University Hospital in Sweden randomly assigned 33 pregnant women with type 1 diabetes to receive either lispro insulin (n=16) or regular insulin (n=17) to maintain normoglycemia during pregnancy.
Patients' blood glucose levels were measured six times daily and glycohemoglobin (HbA[subscript]1c) were determined every 4 weeks. At week 14 of the pregnancies and weeks 21, 28, and 34 of the study, the investigators obtained diurnal blood glucose profiles.
Although women in the lispro group had significantly lower blood glucose concentrations after breakfast (p
Glycohemoglobin (HbA[subscript]1c) levels were similar in the two groups at the beginning of the trial and dropped to comparable levels during the study period. No deaths occurred during the perinatal period, and the groups were similar in regard to complication rate, type of delivery, and general fetal health.
"The results suggest that it is possible to achieve at least as adequate glycemic control with lispro as with regular insulin therapy in type 1 diabetic pregnancies," concluded Persson and associates (Insulin lispro therapy in pregnancies complicated by type 1 diabetes mellitus. Diab Res Clin Pract, 2002;58(2):115-121).
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