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New method shown to be effective for detection at mid-trimester scan.(nasal bone analysis of fetus could aid in Down syndrome detection)
2003 JAN 9 - (NewsRx.com & NewsRx.net) -- Looking at the nasal bones of fetuses at the mid-trimester scan could improve the detection of Down syndrome during pregnancy, according to new study results.
The most frequently occurring chromosomal abnormality, Down syndrome affects every 1 in 500 to 600 live births. This genetic condition arises from an error in cell division that results in an extra copy of chromosome 21. More mature women have an increased chance of carrying a baby with chromosomal abnormalities, so they are offered amniocentesis, a procedure that involves taking a sample of amniotic fluid. This is currently the most effective way of testing for Down syndrome, but there is a risk that miscarriage can be induced.
Professor Kypros Nicolaides of King's Hospital Medical School has previously demonstrated using ultrasound that in the early stages of gestation the nasal bone is underdeveloped in about 70% of fetuses with a chromosomal anomaly, but in fewer than 1% of normal fetuses.
Now for the first time Nicolaides and his team of researchers have studied the incidence of absent nasal bones in chromosomally normal and abnormal fetuses at the mid-trimester ...
- New method shown to be effective for detection at mid-trimester scan.
- Newspaper article from: Biotech Week January 8, 2003 700+ words
...The team found that the nasal bone was underdeveloped in 61...Nicolaides, "This shows that nasal bone underdevelopment at the mid-trimester scan is associated with a high...profile for the absence of the nasal bone is incorporated with other...
- Fetal nasal bone anomalies are highly predictive of down syndrome. (May Reduce...
- Magazine article from: OB GYN News Goldman, Erik L. May 15, 2002 700+ words
BOSTON -- Absence of nasal bone ossification, detectable with ultrasound...fetuses show complete absence of nasal bone ossification, while others show...of the same gestational age. The nasal bone abnormalities are the latest in a...
- Chondroma of the nasal bone: a case report.
- Magazine article from: Ear, Nose and Throat Journal Sreedharan, Suja Kamath, Mulki Pandurang Hegde, Mahesh Chandra Sundar, Seshachalam Lobo, Flora D. Raju, Penumetcha Krishnam January 1, 2006 700+ words
...new case in which a chondroma of the nasal bone caused an external nasal deformity in...case of a chondroma arising from the nasal bone. The authors have made an attempt to...rare case of chondroma arising from the nasal bone. We discuss the problems encountered...
- Short fetal nasal bone tied to 35% rise in down risk. (First Trimester).
- Magazine article from: OB GYN News Boschert, Sherry February 1, 2003 700+ words
NEW YORK -- A short fetal nasal bone--not just a lack of one--was...reported. The absence of a fetal nasal bone on first-trimester ultrasound...the images of any visible fetal nasal bone to determine its size. The median...
- Fetal nasal bone length shown to be independent of maternal factors.(Obstetrics)
- Magazine article from: OB GYN News Brunk, Doug October 1, 2004 700+ words
...ethnic origin. In one British study of nasal bone hyoplasia at 15-22 weeks' gestation...2002 and July 2003. They measured fetal nasal bone length and crown-rump length and recorded...imaging. There was no difference in nasal bone length among the fetuses of Asian, black...
- Missing fetal nasal bone refines trisomy 21 Dx. (Ultrasound Screening at 11-14...
- Magazine article from: OB GYN News Walsh, Nancy February 1, 2002 700+ words
...screening for the absence of a fetal nasal bone at 11-14 weeks' gestation is a new...karyotyping to have trisomy 21, the nasal bone was noted to be absent on ultrasound...603 normal-karyotype fetuses, the nasal bone was absent in only 3 (0.5%). Screening...
- Sensitivity of only 9%: no place for nasal bone evaluation by ultrasound in...
- Magazine article from: OB GYN News Sullivan, Michele G. March 15, 2004 700+ words
NEW ORLEANS -- First-trimester nasal bone evaluation by ultrasound appears to be...of Risk for Aneuploidy (FASTER). "Nasal bone evaluation failed to identify even one...aneuploidy in the general population." Nasal bone images were obtained from 6,316 FASTER...
- Hominoid lineages and keystone clues. (using nasal bone outlines to classify...
- Magazine article from: Science News Bower, Bruce August 1, 1987 700+ words
...crania had been collected in the wild. Nasal bone outlines sometimes displayconfusing similarities...There is certainly variation in hominoid nasal bone anatomy,' responds Olson, "but there...specimens fit my previous description [of nasal bone outlines] in hominoid groups.' On...
Source: HighBeam Research, New method shown to be effective for detection at mid-trimester...