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Change on enzyme gene may associate with invasive disease.(breast cancer invasiveness)
2003 JAN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A solitary polymorphism on the promoter that drives matrix metalloproteinase (MMP)-3 may be responsible for the invasive nature of some breast cancers.
MMP-3 is an enzyme that breaks down the proteins that hold cells adjacent to one another. The breakdown of these extracellular proteins fosters tumor neovascularization, tumor invasion, and tumor metastasis. Researchers in Milan, Italy think an adenine insertion/deletion polymorphism (5A/6A) on the MMP-3 promoter might advance breast cancer invasion and metastasis in some women.
Study leaders from the Universita degli Studi di Milano, in collaboration with colleagues from the Ospedale San Paolo, investigated the gene in 86 breast cancer patients and in 110 age-matched women without cancer.
"The frequency of 5A allele was higher in the breast cancer group than in controls (p=0.035; odds ratio (OR) 1.53; 95% confidence interval (CI), 1.02-2.29)," reported Giorgio Ghilardi and coworkers in the university's Department of Medical Surgery and Dentistry.
Further subdivision of the women with metastatic breast cancer (M+) from those without cancer metastasis (M-) revealed more information about the gene polymorphism. "At the time of diagnosis, the 5A allele was more prevalent in the M+ ...
- Change on enzyme gene may associate with invasive disease.
- Newspaper article from: Angiogenesis Weekly January 10, 2003 700+ words
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Source: HighBeam Research, Change on enzyme gene may associate with invasive disease.(breast...