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Postmenopausal women who stop smoking lower bone loss protein.
2003 JAN 9 - (NewsRx.com & NewsRx.net) -- Postmenopausal women who quit or significantly reduced their smoking for 6 weeks lowered their levels of two proteins involved in bone loss, new research finds.
Levels of the two proteins, a hormone-binding protein called SHBG and a marker of bone loss called NTx, dropped by 8% and 5%, respectively, in the women who quit or cut back on their cigarette intake. Over the same time period, SHBG and NTx levels rose within a control group of women who maintained their smoking habits.
"This may partly explain how smoking contributes to osteoporosis in postmenopausal women," said Cheryl Oncken, MD, MPH, of the University of Connecticut School of Medicine and colleagues.
The study was published in the December 2002 issue of the journal Nicotine & Tobacco Research.
Cigarette smoking increases the long-term risk for weak bone and osteoporosis-type fractures, but whether smoking decreases new bone formation or increases bone loss has been something of a mystery.
To pinpoint smoking's exact effect on bone, Oncken and colleagues examined a variety of hormonal factors and known protein markers of bone loss. The factors included estrogen and testosterone, which help protect against bone loss; SHBG, which binds to these hormones and makes them "available" for the body to use; and several protein markers that indicate bone breakdown or formation.
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Source: HighBeam Research, Postmenopausal women who stop smoking lower bone loss protein.