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Mechanisms of CD8+ T-cell memory persistence studied in lung airways.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Researchers at Trudeau Institute Inc., New York, have studied "the mechanisms underlying the persistence of memory CD8+ T cells in the lung airway lumina following recovery from a respiratory virus infection."
"Recent studies have shown that virus-specific effector memory T cells can be recovered from the lung airways long after clearance of a respiratory virus infection. These cells are thought to play an important role in the recall response to secondary viral infection. It is currently unclear whether these cells actually persist at this site or are maintained by continual proliferation and recruitment," said R.J. Hogan and colleagues.
In the study, they were able to "identify two distinct populations of memory cells. First, a large population Ag [antigen]-specific CD8+ T cells is deposited in the airways during the acute response to the virus. These cells persist in a functional state for several weeks with minimal further division. Second, a smaller population of Ag-specific CD8+ T cells is maintained in the lung airways by homeostatic proliferation and migration to lung airways after viral clearance.
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- Mechanisms of CD8+ T-cell memory persistence studied in lung airways.
- Newspaper article from: Biotech Week January 8, 2003 700+ words
...Researchers at Trudeau Institute Inc., New...recovered from the lung airways long after...migration to lung airways after viral...cells in the lung airways depends on...Woodland, Trudeau Institute Inc., POB...
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...memory T cells of the lung airways. A similar influx...and colleagues, Trudeau Institute Inc. The researchers...T cells to the lung airways during respiratory...L. Woodland, Trudeau Institute Inc., POB 59...
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Source: HighBeam Research, Mechanisms of CD8+ T-cell memory persistence studied in lung airways.