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2003 JAN 8 - (NewsRx.com & NewsRx.net) -- A week after she was given an experimental dose of smallpox vaccine, Elizabeth Forrester's arm became swollen, her head throbbed and she felt tired and feverish.
"At one point I was like 'cut it off, please cut off my arm,'" she recalled telling her husband when the pain kept her from sleeping.
Forrester, a 26-year-old graduate student, was 1 of 148 people to receive the vaccine in a government study at Vanderbilt University.
Her reaction may be a preview of what hundreds of thousands of people might experience as federal officials prepare to offer the vaccine widely for the first time in three decades.
About 10% of the Vanderbilt subjects - all healthy and between the ages of 18 and 30 - experienced extreme discomfort, with fatigue, fever, loss of appetite and other flu-like symptoms that lasted a day or two, Dr. Tom Talbot said.
In a smaller pilot study at Vanderbilt last summer, about 30% reported illness severe enough to miss work or school.
The study, which began in October and ends in January 2003, is part of a federal effort to protect the nation from a biological attack using smallpox.
Source: HighBeam Research, Vaccine test subjects suffer side effects.